Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells
Researchers at Department of Regenerative Medicine, Royan Institute for Stem Cell Biology and Technology introduced a platform for understanding miRNA dynamic regulation in hair follicular cells in baldness. This study represents that miR-324-3p is depleted in bald stem cells compared to normal hair stem and progenitor cells. The roles of miRNAs affecting Androgenic alopecia in normal and patient’s epithelial hair cells has been investigated in the aforementioned paper.
Androgenic alopecia (AGA) is the most common type of hair loss. Suggested causes for this gradual hair loss include androgen dependence and genetic predisposition. The exact pathogenic mechanism causes hair miniaturization during AGA has not been outlined. MicroRNAs (miRNAs), which are about 22-nucleotide non-coding RNAs, regulate the expression of many genes at the post-transcriptional level, thereby controlling virtually all biological processes and pathways.
Recent evidence has shown a role for non-coding regulatory RNAs, such as microRNAs (miRNAs), in skin and hair disease. MiR-324-3p overexpression impact significantly keratinocytes differentiation program, promotes cell migration and reduces proliferation.
This study has provided a comprehensive assessment of the "miRNome" of normal and AGA follicular stem and progenitor cells. Differentially regulated miRNA signatures highlight several miRNA candidates including miRNA-324-3p as mis-regulated in patient’s stem cells. It has been revealed that miR-324-3p promotes differentiation and migration of cultured keratinocytes likely through the regulation of mitogen-activated protein kinase (MAPK) and transforming growth factor (TGF)-β signaling. Importantly, pharmacological inhibition of the mentioned signaling pathway promotes hair shaft elongation in an organ-culture system.
A platform for understanding miRNA dynamic regulation in follicular stem and progenitor cells in baldness and miR-324-3p as a promising target for its treatment has been offered by researchers.